Most natural IgM antibodies are encoded by germline Ig sequences and are produced in large quantities by both mice and humans in the absence of intentional immunization. Natural IgM are reactive with many conserved epitopes. including those shared by microorganisms and autoantigens. As a result. https://www.spidertattooz.com/Orly-Nail-Lacquer-Combo-Here-Comes-The-Sun-Happy-Camper-p32246/