Oxysterol-binding protein (OSBP)-related proteins (ORPs) 5 and 8 have been shown to deplete the lipid phosphatidylinositol 4-phosphate (PI4P) at sites of membrane contact between the endoplasmic reticulum (ER) and plasma membrane (PM). This is believed to be caused by transport of PI4P from the PM to the ER. where PI4P is degraded by an ER-localized SAC1 phosphatase. This is proposed ... https://www.marcelovicente.com/product-category/reconstructuring-shampoo/